Design, synthesis, and evaluation of resveratrol derivatives as Aß1–42 aggregation inhibitors, antioxidants, and neuroprotective agents
C Lu, Y Guo, J Li, M Yao, Q Liao, Z Xie, X Li - Bioorganic & medicinal …, 2012 - Elsevier
A series of novel resveratrol derivatives were designed, synthesised and evaluated as
potential therapeutic agents for the treatment of Alzheimer's disease. Among these
compounds, compound 7l,(E)-5-(4-(isopropylamino) styryl) benzene-1, 3-diol, exhibited
potent ß-amyloid aggregation inhibition activity, which was confirmed by a ThT fluorescence
assay (71.65% at 20μM) and transmission electron microscopy (TEM). Compound 7l also
exhibited good antioxidant activity (4.12 Trolox equivalents in an oxygen radical absorbance …
potential therapeutic agents for the treatment of Alzheimer's disease. Among these
compounds, compound 7l,(E)-5-(4-(isopropylamino) styryl) benzene-1, 3-diol, exhibited
potent ß-amyloid aggregation inhibition activity, which was confirmed by a ThT fluorescence
assay (71.65% at 20μM) and transmission electron microscopy (TEM). Compound 7l also
exhibited good antioxidant activity (4.12 Trolox equivalents in an oxygen radical absorbance …
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